Question about the line level knob on the back of a e530

A few days ago I bought my first Engl amp/preamp.

Simple rig ..
e530 -> Line Output jack (left) -> ISP Stealth Pro power amp -> 4x12 cab

One thing I noticed was the Line Level knob. I read in the manual what it controls and when I turned it the volume went up.

My question is, based on my setup above, is it safe to turn this knob up? Say 12 o'clock.

Thanks in advance. Just trying to not blow up my new rig.
 
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