I just built a core 2 duo using a e4300/2gig of ram (667) and 500gig of storage.
Installed a trial of vista ultimate and uninstalled it a few days later. Why? Well it installed all the drivers fine,
apps worked fine, hardware worked fine but...
for some reason when you click and drag to select anything the cpu spikes.
Like for instance on the desktop you click and drag to select multiple icons,
or click drag to select a few waveforms in your audio app.
When the cpu would spike I would get audio anomolies through my monitors.
I imagine this will be fixed in the future but it was to much for me to deal with for a $400 OS,
The 4300 overclocks like a madman btw, I'm running @ 3ghz without a voltage increase and it's been stable for about 3 days so far.