PBC6X is probably my favorite switcher out there. Feature packed, awesome desktop app, and their support service is better than about anyone else in the industry. I'll give you a rundown of what I do with my RJM PBC6X so you can kinda get an idea of workflow:
Page 1 - Mesa JP2C
Button 1 (Clean: ) Change JP2C to CH1, turn JP2C EQ1 off, turn JP2c EQ2 off, turn JP2C reverb on (on its own IA button if I want to toggle it), turn JP2C FX loop on, turn Ego compressor on and order it in the front of the chain, turn the H90 on and order it in the FX loop with two algorithms in that path for my clean (micropitch and delay), turn on the Boss DC-2W and order it in the loop before the H90. This gives me a compressor, chorus, micropitch (subtle widening), delay, and reverb
Button 2 (Crunch: ) Change JP2C to CH2, turn JP2C EQ1 on, turn JP2C reverb off, turn JP2C FX loop on, turn off shred mode (on its own IA button if I want to toggle it), enable noise gate fed via tuner out for the trigger but order the actual loop to be the first in the FX loop chain, turn on boost 1 ordered in front of the amp, bypass H90 (important for spillover)
Button 3 (Heavy rhythm: ) Change JP2C to CH3, turn JP2C EQ1 on, turn JP2C reverb off, turn JP2C FX loop on, turn off shred mode (on its own IA button if I want to toggle it), enable noise gate fed via tuner out from the trigger but order the actual loop to be first in the FX loop chain, turn on boost 2 ordered in front of the amp, bypass H90 (important for spillover)
Button 4 (Lead: ) Change JP2C to CH3, turn JP2C EQ2 on, turn JP2C reverb off, turn JP2C FX loop on, turn on shred mode (on its own IA button if I want to toggle it), enable my H90 ordered in the FX loop with my delay preset
This kinda stuff is all done at one button press. I have other ones programmed to enable a whammy or wah pedal, ones for different amps I have configured (Savage 120 Mk 2, JVM 410H, etc). Each page I have custom amp setups for custom routings and sounds. I also still have the hold function for the built-in tuner, too.
Did I mention I love my PBC6X?
Best of all, if I ever run into any issues, they respond in less than 24 hours to help me with my rig. Hard to beat that IMO. Great forum support, too.