I'm running one now. I got it because my current main amp has 2 footswitchable master volumes and a dedicated clean channel, also footswitchable. These are all controlled via a single 1/4 inch cable and a two button footswitch... before the joyo PXL anyways.
Now, I can select bank A>button D, for master volume one with my TB09 boost for a brief lead piece, then select Bank A > B for a clean channel with my bogner Harlow boost and a little chorus. I've got my Bank C,D, and E set up for my cover set. Banks A and B are my originals.
Works great, I've played 4 shows with it so far and no head aches. I did have to purchase a single stereo to dual mono cable for my channel switching, but that wasn't too big of a hassle.
The biggest head ache is getting a grasp on how to program the channel switching. I still don't have the process completely down, but I was able to program 8 different patches between 5 pedals, and 3 channels in about a 2 hour period. (From opening the box for the first time to being completely done. ) I'm not sure if the different modes on the Mark V:25 are actually footswitchable though. I do know that Joyo makes a PXL switcher with 2 triggers and a Midi input/output. That might be worth looking into for any midi capable pedals or amps in the future.
Hope this helped