You do need to exercise some caution. Let's say you have a 2x12 cabinet. If both speakers are the same impedance, the power from the amp is divided equally between the two. Now say you have a 100 watt amp. If you have two Vintage 30s, they are rated at 60 watts each and the power is divided between them so at the full 100 watts, each speaker gets 50 watts. This is OK though I would consider pushing things a little bit if you are playing loud, heavy music. Now let's use a Vintage 30 with a 60 watt rating and a Greenback with a 25 watt rating. See any problem??? Both speakers will still be getting 50 watts but the GB can only handle 25 watts.....not good.