Even thought it's not even out, here's my big question:
Since the E2 will reportedly work with any amp that has an effects loop (theoretically bypassing the host amp's preamp so you can use the E2 modules and the host's power amp), does that mean that you have to sacrifice using any actual EFFECTS in the loop because you're using the E2? Or could you run effects AFTER the E2, but BEFORE the power amp IN?
This all just conjecture until anything is actually released, but it might a dealbreaker for some (myself included); in which case, I'd probably ditch my current setup and go with an M4.