I'm against using the impedance selector as a "tone tweak". That's not what it's for and it's very hard on the valves when you mismatch it. Therefore I always keep it matched to the cab configuration I'm using. I run 16R Marshall cabs.
Moreover, I don't play with power amp voltages for the sake of tone tweaking either. I do it all off of a plotted load line and match the impedance ratio of the OT to the B+. This is how true engineers/designers do it. Amps are not "all tone". There is an electrical side to them that also must be adhered to if you don't wanna let the magic smoke out and want a reliable design.