You can run it through anything, IMO. I run them through 4x12s: a Friedman (w/ Scumbacks), a Cameron (w/ Celestions), and a Voodoo (w/ WGS). I run them through 2x12s: a Port City vert (w/ Scumbacks), a Mesa (w/ Scumbacks) and a Voodoo (w/ WGS). I personally like my Voodoos w/ WGS the best for my MTS rigs.