I mess around with more settings, but these are the ones I use the most......they vary depending on which guitar I'm using (Strat, EMG loaded, P90s Les Paul). When I'm playing with the les paul the tone is a bit darker so I might turn the treble/mid/ a bit more than when I'm using the strat. Same goes with the EMG loaded guitar.....the amp sounds meaner and with EMGs I get more gain out of the amp.
I said that I would!! Here's the prototype, cab is a Framus Dragon 4x12 with v30s and Weber beam blockers (which I may remove).
As a note the treble & bass controls function is reversed, and I don't use the reverb at the moment. Presence & deep I adjust according to the room I'm in.
I primarily use mode 3/mega (tight metal rhythm through to Tool-esque and even stoner rock... all on the same settings ), occasionally use mode 1/clean (very nice, almost sounds chorused), and lead channel is for parts that I wish to get a more saturated sound on rather then specifically lead stuff (more channel volume to compensate for added gain and less mids).
As a note, the other guitarist in my band uses a 7 string into an Engl Invader 150. I let him cover the bottom end of the EQ curve with that as I spend most of my time using 6 strings.