The Lead 12 is freaking nuts man. I've owned all sorts of amps. I bought that little one because it was too cheap not to grab with a vertical 2x12. The vert cab turned into a great cat playground eventually lol I used the head through a 4x12 during band rehearsal and it was blowing my other amp out of the water. Kinda pissed me off to be honest! I ended up pushing it to the side for whatever reason and then sold it for next to nothing. The guy I sold it to said, you know you can modify one MOSFET in this and it goes to 100w? This is basically a JCM800. Thanks! I was like... Enjoy! Then years later .. what did I do? That amp sounds great. Found a guy selling one locally for $150.
I have ran it through multiple cabs and it fucking kills man. I sent him a clip with just my LP plugged in and he was shocked. So glad I was able to get it back. The main cab I use it with now is an oversized 1x12 with a WGS Vet30. Works super well together.
Again, High input, Volume all the way up and gain to taste. Super thick, punchy sound that can take pedals well. No FX loop.
Ran w strat, tele, LP, 68 mustang, etc.
Crank the bass, and mids, cut highs. Done.