you're going to get a lot of answers here. in theory (from the amp designers around here, and some of the engineers), some amps can't handle the flyback voltage, from what i've been told. some ppl will also tell you it's ok with solid state to be lower on the amp side than the speaker side....but not with tubes...to match up perfectly. i'd argue that most speakers are never the impedence thats rated on them anyway (which, by the way you CANNOT measure with a voltmeter or digital multimeter...you're trying to measure inductance in this case, not actual resistance)
others, like the mesa, actually will recommend you mismatching ohms....in this case,
16x8=128
128/(16+8)=5.33333333
setting the head on 4 ohms you should be fine. i wouldnt run it on 8 or 16 though, regardless of what mesa says.
quick answer, as long as your ohms of your cabs are greater (as in above equation) than the setting you have your head on, you SHOULD be find with most tube amps made today.
here's a pretty back and forth thread.
again, in short, head on 4, you'll be fine with a mesa.
viewtopic.php?f=3&t=93230&p=1100280&hilit=ohms#p1100280
viewtopic.php?f=3&t=104641&p=1230710&hilit=ohms#p1230710
viewtopic.php?f=3&t=108757&p=1276825&hilit=ohms#p1276825