if it has a locking nut, there's no difference other than cosmetic, and practical (for tuning and string changes).
if you have a regular nut, there's definitely a difference! theoretically, the tension of the high unwound strings will decrease and increase for the low wound strings. but that is only according to length. the angle behind the nut also makes a difference for how effectively the string is terminated.
the playability is not improved imho, especially if you want to do behind the nut bends. but appearance wise it rules!
i play a reverse headstock standard with non locking 2-point trem as my #1 ...
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