I have been playing guitar since the 80s and have owned and gigged with tubes, solid state, digital, etc. I'm also a huge fan of the BOSS Katana and owned one until several weeks ago.
To me, all have their place. When I gigged back in the day with a Tube Works solid state power amp, Tech-21 PSA-1 and Marshall 4x12, it was some of the most killer tube sounds I ever had. The Katana is awesome but not to that level.
Tube amps are revered for a reason. Once tubes warm up, a combination of sustain, warmth, crunch, etc all come together and just has a "chug' "singing", etc, etc. It is easy to get close to that sound but needs many different aspects. That is just my opinion.
Tube amps can be a pain in the ass. For a gig, as an example, you have to predict failure, just in case it happens. Gotta have spare tubes or a spare amp, fuse, and they are heavier obviously. I'm just making sure I have a backup because I love my 5150-III tones that much. I'll probably get a Tech-21 product as a backup when I'm gigging but hopefully won't need it.
My Axefx had phenomenal tones into a computer and people are getting some great live tones with LINE 6, Fractal, etc. I like using my pedals and a 5150-III head right now. Maybe one day I'll go lighter.
As others mentioned, there was a harshness with the Katana that I knew would drive me batty eventually. I love the tones but they should tweak the EQ more.