Short answer, yes…
Long answer, is it a tube that is matched to the set that’s in there?
Are you sure which tube it is?
You could keep blowing fuses until you find the right one.
And then, when you do find the right one, maybe the tube that you put in, (unless it is matched to the other ones), will red plate etc. etc.
So, yes, if you know the bad culprit, you can replace it with another one as long as its at least within bias range to the tubes which are already in there, or at least somewhere ‘remotely close’ range…
I’ve replaced one tube at a show and it was way way on the cold side, when I checked the next day in the morning, it was only pulling 17 mA where is the other ones were at 35 mA but as long as the one you put in as colder and not way too hot, at least you’ll be safe, maybe not the optimum tone however, but ‘safe’.
Edit… I have a few friends that do not like closely matched quads in their amplifiers, they prefer hotter ones in the outside sockets and the cooler ones on the inside and they seem to feel they get a more full range tone…
I guess it’s all subjective.
I have never tried this method, I have always just used matched quads, but it would be interesting to try someday. Who knows, depending on the amplifier, Maybe they’re right.