Touches it for what? What is the context of your application? Yes, in the room the 412 will sound fuller- although some 212s come very close. In the mix? You're going to mic a single speaker.
I switched to using IRs last year for live shows. What I noticed was that my live tone became very consistent regardless of what venue we were playing. I still get compliments on my tone. So this year I decided to pickup a 212. Why haul the extra weight?
In my 30 plus years of playing, I have come to one conclusion... The tone chasing that we as guitarists do is only for us. No one in the audience can tell the difference between a Marshall, Splawn, Bogner or Friedman. They only care that it sounds good and you are playing a song that they dig.