I don't use boosts, od, dist, with my amps; I like the sound of my amps, and rarely use any effects except an EQ with a few exceptions.
I tend to go for '70s hard rock (e.g., Kiss), '80s hair metal, fusion and prog tones, and have different rigs for most. I try using the least amount of gear I can get away with.
For prog, I have a Mesa JP-2C, and I use my HX-Effects in 4CM; I sometimes use my FuzzFactory in front of my 1959x, and I have a Hendrix patch in my HX-Effects I use in front of the SLP.
I tend to use more effects with my computer software rig, my digital modelers, and my preamp/effects rigs (ISP Theta Michael Sweet).