I put up a poll and thread about the claim some people can always tell the difference between profiles and the real deal from recordings.
https://www.rig-talk.com/forum/threads/golden-ears.219513/
It also points out how even amp identification can be wrong.
It explains the complexity of speaker types, microphone type, and placement.
There isn't really much to say about that difference except any can be matched by tweaking both rigs.
Only in certain circumstances where a guitarist uses a stack on stage will they be able to feel the volume of air and sound directionally coming at them and around them. FRFR or monitor speakers are wider spreading. That means the feeling of air moving can be a little different. You can imagine standing and closing your eyes to different types of airflow systems matching some sounds basically. However, if you are gigging with the need for 2x12 or 4x12 guitar speaker cabinets then chances are the venue will want loudspeakers of more wattage than your rig. These will be FRFR speakers onto the audience. That is what they will hear because it is louder than your rig.
The distance between you and that system matters also. If that was aimed at you then you would be getting feedback. Your strings would be picking up resonance from those monitors. Even with musician front monitors. Even a profiler on stage if played through a guitar FFRFR speaker cab system like a Mission or Friedman can feedback the same way.
- Frequency Range: 50Hz - 20kHz
- Frequency Response: 58Hz -18kHz
The Line6 Powercab happens to be a power amp in a cab for modelers.
I am not saying these are like the airflow from tube combos or 4x12 stacks.
Do you ever see that 1x12 or 2x12 rectangular floor combo used by some bands since forever in among bigger speakers and other gear to supplement the tone? Usually, that smaller system is producing the tones in the in-ear monitors of the guitarist. Modern examples include the Mesa Boogie Mark V combos or head turned up loud. A profiler can do this also. Fender custom tweed deluxe amps are another example of that small system being the real tone among the touring rig up on stage for guitarists. Vox AC30 is another popular combo for this. Sometimes they might even be off stage or behind a rig wall. U2 decided on a larger visual performance being stage gear minimalists. They basically have a bunker. In that bunker, the amps being microphoned up are there on the floor with their amp engineer maintaining it all.