Best advice I still use regularly 5 years into owning Fractal gear-
Get your cab/IR picked before you start turning knobs on the amp, unless it’s a Mesa. I swear more people end up in rabbit holes they believe ALL those fuckin’ parameters are going to dial them out of when if they picked a good IR to begin with, they can just turn the amp knobs on the Tone page and be done with it, like a real amp.
I’m all about the DynaCabs these days. I haven’t touched an IR since they’ve been released, there’s no need and the IR search is the most tedious part of it all.
The other night I went to mod a 50-watt Plexi into a Jose, loaded the amp and cab blocks, picked the Friedman GB cabinet and didn’t touch the mic, went over and tweaked the reverb and then noodled for about 15 minutes before I realized I hadn’t touched the amp or cab block yet, everything was at noon with the mic in the dead center of the cab.
So if you load an IR or you’re on a DynaCab that isn’t sounding good or in the ballpark right out of the gate, fuck it, move on until you get there. Don’t let all the options convince you that it should be different than dialing in a regular amp. Pretend they don’t even exist until you’re stoked with your tone and have the desire to dig deeper and find something different in it.
FWIW, this is where I ended up with the Jose-mod on the 6CA7 Plexi (vintage voiced single coils on the Strat I’m playing), it took about 4 minutes to get there-