I did a gig recently accompanying an acoustic player, where I was trying to sit in that sweet spot. The clean channel of my mark V, blue (bluesbreaker) side of a browne protein, a little bucket delay in the loop, and the center pickup position on my tele seemed to do the trick; riding the volume & tone controls a lot, and trying to pick very lightly for the most part. Always felt like I was riding that line gain-wise between overpowering & getting lost.
It actually left me wishing I had a humbucker equipped guitar that covered that range better, everything I have is way too hot.