+1.
Also, if you're using powered PA speakers, you may want to try using a global eq to cut the lows and highs.
As I mentioned in my prior post, the factory presets in my software plugins usually sound very good if it's a tone I like. Like hardware modelers, some of the factory presets are just overdone with effects...
The factory presets in my Helix have fewer tones I like, until I started turning off everything but the amp and cab. I also use the global eq to cut the lows and highs I don't need. I also don't drop tune, at most a half step.
What I found to work for me is to create a new patch with an amp and cab, dial them in; then use the default mic on the cab block and move it around to where I like it best, try other mics, etc. I'm in the slow process of creating a set of basic amp + cab + mic + mic placement patches that I will copy into new patches as a starting point.