I may get lynched for reccomending 2 normal brand names..
I have a Boss GT-8 that i run occasionally in the 4 cable Method (4CM) with my 4100, and I midi control my GT-8..
maybe look at the GT-10, see and listen if what it offers is what you want. I think that after Axe FX, the GT-8/ GT-10 with certain processing (known as the harmonic converger) hold the best tone for digital modelers.. the 10 verbs are much improved... the verb on the 8 is a weakness for that unit (especially the nasty spring verb)
...though POD has been removing a lot of what I hate out of their tone... I was shocked to actually hear good satisifying pod tone from one for the first time this last year! the x3 has good internal routing and choices on modeled boxes. I can't comment on the quality of the Pod verbs.
every MFX (Ax less than others) have some shortcomings.. just try first.
though, if you reallllly want good delay- just get an analog delay. Moog is best, malekko and carbon copy are good too.