I've done countless acoustic shows both with my full band and as part of a duet where I play and sing and I've used the
Fender tonemaster pro (was my favorite all in one unit) into my 1st gen ZLX FRFR, I've used the 2nd gen ZLX FRFR, the big fishman loudbox, I've used the Fractal FM3 and AxeFX III and most recently, my quad cortex.
They all get the job done but I think that the tonemaster pro was the best in terms of just doing everything effortlessly and being the best stage device to work with. Although it has a built in acoustisonic amp model, I still ended up preferring the tube preamp model with a couple of acoustic IR's from worship tutorials. Vocal processing on it was great.
The FM3 couldn't really do both vocal processing and guitar so I used a TC Helicon mic mechanic for my vocals when using the FM3 but in terms of guitar processing, IR block, etc, it worked well.
The quad cortex has also been great and about on par for acoustic stuff as the AxeFX III where I can run a signal path for my guitar, my vocal mic and if I'm using one of those acoustic electric guitars like the
PRS Piezo or something like that with dual outputs, I can run both instrument cables into the QC or AxeFX III and setup channel switching to jump from acoustic to electric pickups and flip over to an amp model for high gain lead stuff.
Think "An evening with Petrucci and Rudess" type switching.
The nice thing about the AxeFX III was that when I was doing duet work, the singer would also run his vocal mic into the unit to get all the vocal stuff and have his own dedicated voice track.
As for amplification, I really liked the 2nd Gen ZLX. It has a bluetooth companion app that works really well and lets you add effects to the 2 channels independently so if you just want to plug a guitar and mic into the ZLX, you can setup compression, EQ and reverb on each channel.
The loudbox was pretty good and, like the name implies, very loud. I was bummed that you couldn't footswitch control effect 2. Also, it's kinda expensive for what it is but it's smaller and lighter than the FRFR's though not quite as loud.