Yep. In your shop policies, you can set terms for your returns, as well as restocking fees. Under the General Terms and Special Conditions, you can add whatever "fine print" you need to protect yourself. For example, I require any issues to be reported within 72 hours, and any damage in shipping within 24. I also set terms for them to cover shipping in both directions when something is returned for subjective reasons.
As tempting as it is to take an as-is, no returns approach, I'd rather take something back over a change of heart, than to have a buyer damage the item or otherwise manufacture a reason for a not-as-described return. When you accept returns, I think it disarms the buyer a bit. Then they can request a return for any reason, without having to posture for a fight. Almost no one reads shop policies ahead of time, especially when they see that you accept returns in your item listing. By the time they find out that I won't refund their shipping, etc., they've already confirmed that the item was fine, just not what they wanted, and good luck convincing Reverb support of a not-as-described claim by that point ;-)