Several years ago, decided to check out modeling. I tried a Kemper, was not for me personally. This is not an anti-Kemper rant, so please bear with me.
Got an Axe FX III and a XiTone powered 1x12. There was clearly a difference from a tube amp and 4x12. The Axe FX has a plethora of connection including 4 dedicated stereo inputs/outputs. This is also not an Axe FX pitch...
I decided to try an experiment. I also have a JVM 410 HJS, a 1960 AHW 4x12, and a 1960 TV 4x12. I put the XiTone on AFX Output 1 and the JVM FX Loop Return to AFX Output 4. I integrated AFX Output 3 to the front of the JVM and JVM FX Loop Send to AFX Input 4. So a 4CM setup and an FRFR all in a single rig.
With this I could mix and match any of the components. The preset determines how everything gets stitched together. Changing between an FRFR preset and the JVM was a simple as selecting a preset on my foot controller. I can do things like use an Axe FX model and send it to the JVM FX Return (Which enters the amp circuit after the pre-amp and before power amp stages). Or I can send to the front of the JVM (Preamp), pick up the signal from the FX send, then output it to the XiTone.
I can also insert FX into the preset at any point in the chain.
My goal was to be able to quickly and easily flip between different configurations to do A/B testing without re-wiring and jumping through hoops.
Have tried all the different configurations and the 1x12 does not hold a candle to the 4x12 setup (No surprise there).
The Axe FX amp models run into the JVM output stage have the pant flapping that one would expect when using a tube amp. It is not 100% the same, but it feels right.
Using the JVM preamp and output stage with Axe FX effects feels glorious.
The JVM preamp through the XiTone has the same lack of "chug" that is commonly described with modelers.
Straight up Axe FX and XiTone did not have the feel of the tube amp.
This is where I got to though: all of this is really just me geeking out for myself. Once you mic a tube amp and record it or send it to a PA, the recording/audience/sound engineer are getting what the Kemper or Axe is putting out: a mic capture of a incredibly small part of the larger sonic field that is being produced by the amp. That was the thing that helped me personally to get over the philosophical "hump".
Once I found peace with that, quickly recognized that the tone coming from the Axe FX was the tone that would be recorded or heard by a live audience. While room ambience is still a factor as is the impact of volume, but sound checks got easier and live tone became more consistent.
At home I kept this integrated setup. If recording I will using modeling and IRs with monitoring through a XiTone or studio speakers. If playing for my own enjoyment, it is JVM all the way.