Not my words but this is exactly how it breaks down:
"Series wiring- mid/upper mid and high end emphasis generally, smoother high freqs generally due to damped top end highs in the 5 to 6k range, less fizz. Additional tonal changes are slightly spongier attack and altered OD character, more complex and timbrally rich with more overtones ala the mid and top end emphasis.
Parallel wiring- low end and lower mid emphasis with more top end high sparkle or fizz, depending on the speaker and rig that can make the high end raspy or harsh to some. Low end is emphasized due to increased damping between 2 12" speakers in parallel, generallly tighter and more thump. Parallel- for heavier OD tones, more modern tone as in todays tuned down uber bottom tones with raspy highs, tighter thump think Tool etc
for cleans, more headroom and usable travel on the guitar pot, more high end sparkle in the 5 to 6k range since the parallel spkr coil config means the extreme high end is not attenuated through each coil in series, more hifi sounding in general with bottom and very top end emphasis
Series- more vintage flavored with less bottom more mids and top end but not as extended into the Presence range of 5 to 6k more suitable for shred where you spend much time on strings 1, 2 and 3 etc. speed picking etc. Too much presence and its Razer Blades to the ears. Less headroom overall meaning less clean and its dependent on the rig of course"
I prefer parallel/series with V30 type speakers as that wiring helps extended the bandwidth of the narrow V30 EQ spectrum. Now that I'm back to vintage G12-80s I'm preferring series/parallel as those speakers have a wider more balanced frequency response.