The only two 4x12 cabs I've owned are my 2006 mesa OS cab and my 2006 avatar vintage cab. The mesa has a nice balanced wall of sound kinda vibe and the avatar cab is more focused and tight. I use them both depending on how I'm feeling. To me, nothing compares to a 4x12 and I've owned a couple 2x12's before, but they just don't hold up at high volumes like a 4x12.
Edit: both of my cabs have v30's from various years, like my avatar cab has a couple v30's from 2021 that sound really nice and smooth and a couple v30's from 2006 that are brighter but well broken in. It's a nice combination.